Panama Canal is one of the main maritime trade routes and is located in Central America. The canal is no less than 77km long. It passes through the Isthmus of Panama, which is located between the Caribbean Sea and the Pacific Ocean. This canal also links two oceans, the Atlantic and the Pacific. In 1914, the Panama Canal was opened to free circulation, thus provoking a real revolution in navigation.

Your Panama Canal cruise will take you to beautiful countries such as Colombia, Honduras, Mexico, Panama and Costa Rica. In addition, you will feel like a true traveler as you sail in the wake of famous navigators such as Vasco Núñez de Balboa. Most of the time, the cruises will leave from big cities in the United States like Miami, Los Angeles or from South American cities like San Jose in Costa Rica.

You will be charmed by the beauty of Panama. From its colorful mosaics to its nuanced landscapes, let yourself be transported on an unforgettable escapade where you will discover natural phenomena such as the Baru volcano. From up there, you can enjoy the best view in Panama. 

Departure Months

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Panama Canal : Panama, United States, Costa Rica, Mexico - Serenade of the Seas

Itinerary : Colon, Los Angeles, Puntarenas, Huatulco, Puerto Vallarta

Panama Canal : Panama, United States, Costa Rica, Mexico - Serenade of the Seas

From $387

Full board
Full board Port taxes included

From $387

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Departure :

25 April 26

Caribbean-Antilles : Colombia, Aruba, Curacao, Panama - Grandeur of the Seas

Itinerary : Carthagène, Oranjestad, Willemstad, Colon, Carthagène

Caribbean-Antilles : Colombia, Aruba, Curacao, Panama - Grandeur of the Seas

From $725

Full board
Full board Port taxes included

From $725

Caribbean-Antilles : Colombia, Aruba, Bonaire, Panama - Grandeur of the Seas

Itinerary : Carthagène, Oranjestad, Kralendijk, Colon, Carthagène

Caribbean-Antilles : Colombia, Aruba, Bonaire, Panama - Grandeur of the Seas

From $735

Full board
Full board Port taxes included

From $735

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Departure :

14 February 27

Caribbean-Antilles : Colombia, Curacao, Aruba, Panama - Grandeur of the Seas

Itinerary : Carthagène, Willemstad, Oranjestad, Colon, Carthagène

Caribbean-Antilles : Colombia, Curacao, Aruba, Panama - Grandeur of the Seas

From $779

Full board
Full board Port taxes included

From $779

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17 January 27

19 December 27

Other departures

Caribbean-Antilles : Colombia, Curacao, Aruba, Panama - Grandeur of the Seas

Itinerary : Carthagène, Willemstad, Oranjestad, Colon, Carthagène

Caribbean-Antilles : Colombia, Curacao, Aruba, Panama - Grandeur of the Seas

From $779

Full board
Full board Port taxes included

From $779

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2-23 January 28

Other departures

Caribbean-Antilles : Colombia, Aruba, Curacao, Panama - Grandeur of the Seas

Itinerary : Carthagène, Oranjestad, Willemstad, Colon, Carthagène

Caribbean-Antilles : Colombia, Aruba, Curacao, Panama - Grandeur of the Seas

From $809

Full board
Full board Port taxes included

From $809

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Departure :

9 January 28

Caribbean : United States, Jamaica, Colombia, Panama, Costa Rica, Honduras, Bahamian - MSC Divina

Itinerary : Miami, Ocho Rios, Carthagène, Colon, Limon Port, Roatan, MSC Ocean Cay Marine Reserve, Miami

Caribbean : United States, Jamaica, Colombia, Panama, Costa Rica, Honduras, Bahamian - MSC Divina

From $1,389
-41% $819

Full board
Full board Free for Children * Port taxes included Europe's most modern fleet Kids club
  • Departure Port : Miami Duration : 12 Days
  • Duration : 12 Days From $1,389 -41% $819
  • Boat : MSC Divina
  • Company : MSC Cruises

From $1,389 -41% $819

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Departure :

1 March 26

Caribbean-Antilles : Colombia, Curacao, Bonaire, Aruba, Panama - Grandeur of the Seas

Itinerary : Carthagène, Willemstad, Kralendijk, Oranjestad, Colon, Carthagène

Caribbean-Antilles : Colombia, Curacao, Bonaire, Aruba, Panama - Grandeur of the Seas

From $844

Full board
Full board Port taxes included

From $844

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Departures :

14-28 March 27

Caribbean-Antilles : Colombia, Curacao, Aruba, Bonaire, Panama - Grandeur of the Seas

Itinerary : Carthagène, Willemstad, Oranjestad, Kralendijk, Colon, Carthagène

Caribbean-Antilles : Colombia, Curacao, Aruba, Bonaire, Panama - Grandeur of the Seas

From $847

Full board
Full board Port taxes included

From $847

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Departure :

31 January 27

Caribbean-Antilles : Colombia, Aruba, Bonaire, Curacao, Panama - Grandeur of the Seas

Itinerary : Carthagène, Oranjestad, Kralendijk, Willemstad, Colon, Carthagène

Caribbean-Antilles : Colombia, Aruba, Bonaire, Curacao, Panama - Grandeur of the Seas

From $854

Full board
Full board Port taxes included

From $854

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Departure :

11 April 27

Caribbean-Antilles : Panama, Bonaire, Aruba, Curacao, Trinidad and Tobago - Grandeur of the Seas

Itinerary : Colon, Colon, Kralendijk, Oranjestad, Willemstad, Port of Spain, Scarborough

Caribbean-Antilles : Panama, Bonaire, Aruba, Curacao, Trinidad and Tobago - Grandeur of the Seas

From $874

Full board
Full board Port taxes included

From $874

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Departure :

14 November 26

Caribbean-Antilles : Colombia, Curacao, Aruba, Panama - Grandeur of the Seas

Itinerary : Carthagène, Willemstad, Oranjestad, Colon, Carthagène

Caribbean-Antilles : Colombia, Curacao, Aruba, Panama - Grandeur of the Seas

From $879

Full board
Full board Port taxes included

From $879

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Departure :

19 March 28

Caribbean-Antilles : Colombia, Bonaire, Curacao, Aruba, Panama - Grandeur of the Seas

Itinerary : Carthagène, Kralendijk, Willemstad, Oranjestad, Colon, Carthagène

Caribbean-Antilles : Colombia, Bonaire, Curacao, Aruba, Panama - Grandeur of the Seas

From $900

Full board
Full board Port taxes included

From $900

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Departure :

24 January 27

Caribbean-Antilles : Colombia, Bonaire, Aruba, Curacao, Panama - Grandeur of the Seas

Itinerary : Carthagène, Kralendijk, Oranjestad, Willemstad, Colon, Carthagène

Caribbean-Antilles : Colombia, Bonaire, Aruba, Curacao, Panama - Grandeur of the Seas

From $919

Full board
Full board Port taxes included

From $919

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Departures :

6 September 26

2 April 28

Caribbean : United States, Jamaica, Colombia, Panama, Costa Rica, Honduras, Belize - MSC Poesia

Itinerary : Miami, Ocho Rios, Carthagène, Colon, Limon Port, Roatan, Belize, Miami

Caribbean : United States, Jamaica, Colombia, Panama, Costa Rica, Honduras, Belize - MSC Poesia

From $939

Full board
Full board Free for Children * Port taxes included Europe's most modern fleet Kids club
  • Departure Port : Miami Duration : 12 Days
  • Duration : 12 Days From $939
  • Boat : MSC Poesia
  • Company : MSC Cruises

From $939

Caribbean-Antilles : Colombia, Aruba, Bonaire, Panama - Grandeur of the Seas

Itinerary : Carthagène, Oranjestad, Kralendijk, Colon, Carthagène

Caribbean-Antilles : Colombia, Aruba, Bonaire, Panama - Grandeur of the Seas

From $1,017

Full board
Full board Port taxes included

From $1,017

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Departure :

20 December 26

Caribbean : United States, Jamaica, Colombia, Panama, Costa Rica, Honduras, Belize - MSC Poesia

Itinerary : Miami, Montego Bay, Carthagène, Colon, Limon Port, Roatan, Belize, Miami

Caribbean : United States, Jamaica, Colombia, Panama, Costa Rica, Honduras, Belize - MSC Poesia

From $1,039

Full board
Full board Free for Children * Port taxes included Europe's most modern fleet Kids club
  • Departure Port : Miami Duration : 12 Days
  • Duration : 12 Days From $1,039
  • Boat : MSC Poesia
  • Company : MSC Cruises

From $1,039

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3-24 January 27

23 January 28

Caribbean-Antilles : Colombia, Aruba, Curacao, Panama - Serenade of the Seas

Itinerary : Carthagène, Oranjestad, Willemstad, Colon, Carthagène

Caribbean-Antilles : Colombia, Aruba, Curacao, Panama - Serenade of the Seas

From $1,049

Full board
Full board Port taxes included

From $1,049

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15 February 26

22 March 26

Other departures

Caribbean-Antilles : Colombia, Curacao, Aruba, Panama - Serenade of the Seas

Itinerary : Carthagène, Willemstad, Oranjestad, Colon, Carthagène

Caribbean-Antilles : Colombia, Curacao, Aruba, Panama - Serenade of the Seas

From $1,109

Full board
Full board Port taxes included

From $1,109

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Departures :

15 March 26

12 April 26

Caribbean : United States, Jamaica, Aruba, Colombia, Panama, Honduras, Bahamian - MSC Divina

Itinerary : Miami, Ocho Rios, Oranjestad, Carthagène, Colon, Roatan, MSC Ocean Cay Marine Reserve, Miami

Caribbean : United States, Jamaica, Aruba, Colombia, Panama, Honduras, Bahamian - MSC Divina

From $1,449
-20% $1,159

Full board
Full board Free for Children * Port taxes included Europe's most modern fleet Kids club
  • Departure Port : Miami Duration : 12 Days
  • Duration : 12 Days From $1,449 -20% $1,159
  • Boat : MSC Divina
  • Company : MSC Cruises

From $1,449 -20% $1,159

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Departure :

29 March 26

Panama Canal : United States, Guatemala, Mexico, Cayman Islands, Colombia, Panama, Costa Rica - Celebrity Summit

Itinerary : Fort Lauderdale Miami, Port Quetzal, Puerto Vallarta, Mazatlan, Los Angeles, George Town, Carthagène, Colon, Puntarenas

Panama Canal : United States, Guatemala, Mexico, Cayman Islands, Colombia, Panama, Costa Rica - Celebrity Summit

From $1,208

Full board
Full board All Included Offer Available

From $1,208

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Departure :

13 April 26

Panama Canal : United States, Colombia, Jamaica, Cayman Islands, Mexico, Guatemala, Costa Rica - Celebrity Summit

Itinerary : Los Angeles, Carthagène, Ocho Rios, George Town, Tampa, Puerto Vallarta, Port Quetzal, Puntarenas

Panama Canal : United States, Colombia, Jamaica, Cayman Islands, Mexico, Guatemala, Costa Rica - Celebrity Summit

From $1,213

Full board
Full board All Included Offer Available

From $1,213

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Departure :

1 October 26

Caribbean : United States, Bahamian, Mexico, Cayman Islands, Jamaica, Aruba, Colombia, Panama, Honduras - MSC Divina

Itinerary : Miami, MSC Ocean Cay Marine Reserve, Cozumel, George Town, Ocho Rios, Miami, Ocho Rios, Oranjestad, Carthagène, Colon, Roatan, MSC Ocean Cay Marine Reserve, Miami

Caribbean : United States, Bahamian, Mexico, Cayman Islands, Jamaica, Aruba, Colombia, Panama, Honduras - MSC Divina

From $2,179
-39% $1,329

Full board
Full board Free for Children * Port taxes included Europe's most modern fleet Kids club
  • Departure Port : Miami Duration : 19 Days
  • Duration : 19 Days From $2,179 -39% $1,329
  • Boat : MSC Divina
  • Company : MSC Cruises

From $2,179 -39% $1,329

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Departure :

22 March 26

Caribbean-Antilles : Colombia, Aruba, Bonaire, Panama - Serenade of the Seas

Itinerary : Carthagène, Oranjestad, Kralendijk, Colon, Carthagène

Caribbean-Antilles : Colombia, Aruba, Bonaire, Panama - Serenade of the Seas

From $1,399

Full board
Full board Port taxes included

From $1,399

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Departure :

29 March 26

Panama Canal : United States, Bahamian, Aruba, Curacao, Panama, Cayman Islands -

Itinerary : Fort Lauderdale Miami, Bimini Islands, Fort Lauderdale Miami, Oranjestad, Willemstad, Colon, George Town

Panama Canal : United States, Bahamian, Aruba, Curacao, Panama, Cayman Islands -

From $1,403

Full board
Full board All Included Offer Available
  • Departure Port : Fort Lauderdale Miami Duration : 11 Days
  • Duration : 11 Days From $1,403
  • Boat :
  • Company : Celebrity Cruises

From $1,403

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22 November 27

3 January 28

What is the best period to cruise the Panama Canal?

With tropical temperatures, it will be pleasant to spend a cruise on the Panama Canal. Temperatures are often around 30°C, so you can tan easily. The period from January to April is the dry season. It is during this period that it is best to go on a cruise on the Panama Canal. The period from September to December is rainy so we recommend you to avoid it.